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Q: 5-HT antagonist used to control chemotherapy induced nausea and vomiting
  • A. Risperidone
  • B. Ondansetron
  • C. Cyproheptadine
  • D. Clozapine
Correct Answer: Option B - Gnanisetron, dolasetron and its major metabolites are pure 5-HT3 antagonist while ondansetron and tropisetron are weak antagonist at the 5- HT4 receptor. Ondansetron has also been demonstrated to bind at other serotonin receptors and to the mu opioid receptor
B. Gnanisetron, dolasetron and its major metabolites are pure 5-HT3 antagonist while ondansetron and tropisetron are weak antagonist at the 5- HT4 receptor. Ondansetron has also been demonstrated to bind at other serotonin receptors and to the mu opioid receptor

Explanations:

Gnanisetron, dolasetron and its major metabolites are pure 5-HT3 antagonist while ondansetron and tropisetron are weak antagonist at the 5- HT4 receptor. Ondansetron has also been demonstrated to bind at other serotonin receptors and to the mu opioid receptor